Synbiotic 365

1,250 reviews

Synbiotic 365 is the 3-in-1 gut health solution made with 14 probiotics, herbal prebiotics, and B vitamins.

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Synbiotic 365 is the daily all-in-one prebiotic and probiotic gut health solution made from the finest natural ingredients in the world. This proprietary formula includes 14 powerful probiotic strains, an herbal prebiotic, and a concentrated blend of B vitamins — to help balance your gut microbiome, support healthy digestion, support healthy energy metabolism, and support your weight goals.

  • 30 delayed-release gel capsules
  • No refrigeration required
  • 20 billion CFU (at time of manufacturing)
  • Non-GMO
  • Vegan Certified
  • Allergen Free
  • Formulated in the USA with Internationally-Sourced Ingredients
Supplement Facts

How to Use

  1. 1Take 1 capsule with 8 oz. of water on an empty stomach, 30 minutes before eating.

ingredient spotlight

Lactobacillus gasseri BNR17

This potent probiotic strain has over 20 years of clinical research behind it. Studies have shown that it supports gut health and can even help to reduce waist and hip circumferences.

Explore Ingredient Spotlight
Lactobacillus gasseri BNR17

Benefits of taking Synbiotic 365®

14 probiotic strains with 20 billion CFU

We added 14 unique strains of therapeutic-class probiotics, each selected for their clinically-backed effects on colonizing the gut with good bacteria, improving the functioning of the digestive tract, supporting and protecting the gut lining, and increasing gut biodiversity.

Aids in immune system performance

DE111 at 1 billion CFU to support and boost healthy immune system function. The presence of good bacteria encouraged by Synbiotic 365 further enhances and promotes your immune system’s performance.

Promotes a healthy digestive system

A combination of clinically proven probiotic strains and herbal prebiotics work together to discourage the growth of bad bacteria and boost the vitality and growth of good bacteria for improved functioning of the digestive tract and support of digestive comfort.

Supports weight management goals

Having the proper balance of good bacteria in your gut helps your system break down and digest foods quicker and easier. Better digestive function helps with metabolic health to support weight management.

Boosts metabolism

Synbiotic 365 contains essential B-complex vitamins, which helps prevent mental fatigue and support the metabolism of carbohydrates, amino acids, and fats.

nourishes gut lining and improves energy

Synbiotic 365 is perfect if...

  • You’ve tried other probiotics and prebiotics but still haven’t found a product that works for you.
  • You are looking for an all-in-one product that provides daily maintenance to cover the daily basics of gut health.
  • You want better digestion, less gas, bloating, and regularity.
  • You’re trying to lose weight but dieting and exercise aren’t helping.
  • You’re experiencing Leaky Gut, feeling sluggish and foggy-brained, and want more energy during the day.
  • You want to boost your gut flora and improve your digestive function.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Based on 1,250 Reviews

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Nancy S.

on May 22, 2024

Day 9 on using Synbiotic 365 and it has exceeded my expectations. Not only am I noticing increased gut health but inflammation through my whole body is starting to diminish! Extra energy and improved mood! This stuff is the real deal!

Janice A.

on May 21, 2024

This probiotic has really helped my digestive challenges. I cannot wait to see how things continue to progress.

Peggy P.

on May 17, 2024

I take all of the Nature MD products and have found excellent results and relief of my chronic diarrhea problems. Each product plays a specific role in calming and correcting my severely dysfunctional digestive system, and, together, they form the best all-around plan for addressing my problems that have defined my life for the last few years. To say I am grateful is a huge understatement.

Ulla S.

on May 17, 2024


Sue S.

on May 16, 2024

Five stars

Paul O.

on May 14, 2024

Just about to reorder! Tried it for three months and I can tell it’s working for me. I’ve experienced a much healthier gut and just all around feel better.

Deborah B.

on May 06, 2024

This product has help me calm my digestion. So far I love this product!

Mona A.

on May 01, 2024

I like it

Cindy K.

on May 01, 2024

Synbiotics 365 and Gut Connect 365 are the best products out there for gut health. I have IBS and honestly, these two products allow me to enjoy a healthy lifestyle and I am able to enjoy food again. I stopped taking these for quite a while and had so many stomach issues. Even tried other products with no results. After taking the two products for a week I am now back to my self again. Never going to stop again! I am on auto delivery for both products.

Corene R.

on May 01, 2024

This 365 product is wonderful! I have been taking this daily for several years now and enjoy a very healthy digestive system. Helps to keep all systems moving regularly.